Accidental overdose from opioids (heroin, fentanyl, and others) is a leading cause of death in the US, and increased by 100,000/year from 2020-2021. EMS calls for opioid related issues more than doubled between 2018 and 2020. To respond to this crisis, many LE agencies are equipping officers with naloxone (Narcan) for reversing overdoses prior to EMS arrival. Nalmefene, another opioid antagonist, has recently entered the picture, and is being marketed to many LE agencies. With increased education and availability, many patients suffering from addiction are being treated with buprenorphine (Suboxone, Subutex). Anecdotal reports of officers being incapacitated through passive exposure to fentanyl have led to widespread concern about dangers of interacting with people who may have drugs on them. This presentation will cover the landscape of new issues and innovations in opioids that officers may encounter in their work.